Lets assume your guitar is in standard tuning. If you are not yet able to tune it by ear, use a guitar tuner. If you don't have one, you should get one. It's a good idea to tune your guitar every time you play it. After you have tuned your guitar, tune the low E string to the open D string. You may do this by ear, or with your tuner. 

E||----------------||
B||----------------||
G||----------------||
D||---0------------||
A||----------------||
E||-------0--------|| <- Tune Down

An even easier way is to tune the 7th fret of the E string to an A. This will tune the E string to a D. 

E||----------------||
B||----------------||
G||----------------||
D||----------------||
A||--0-------------||
E||-------7--------|| <- Tune Down

You'll now notice that your guitar sounds a lot more heavier, deeper and more powerful. If you like this kind of sound, you may also want to try tuning the 5th string (A) to a G. (open 3rd string) 

E||----------------||
B||----------------||
G||---0------------||
D||----------------||
A||-------0--------|| <- Tune Down
E||----------------|| 

Or, tune the 7th fret of the A string to the open D string, making the A string now a G. 

E||----------------||
B||----------------||
G||----------------||
D||--0-------------||
A||-------7--------|| <- Tune Down
E||----------------|| 

Trying these different tunings may inspire you to play different sounds and styles. Have fun with it.  

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